Introduction Myalgic Encephalomyelitis (ME), commonly referred to as Chronic Fatigue Syndrome (ME/CFS), is a complex, multisystem condition that affects energy production, neurological function, circulation, immune regulation and the body’s ability to respond to physical and mental demands. Among the many symptoms experienced by people living with ME is persistent or recurring headache. For some individuals, these headaches resemble migraines, while others experience pressure, throbbing, pulsating discomfort or headaches that become worse when standing, sitting upright or engaging in everyday activities. An area of growing scientific interest is the relationship between ME and vascular dysfunction. The vascular system is responsible for delivering oxygen and nutrients to the brain and other tissues.…